Once hematopoiesis is established in the bone marrow, a continuous egress of hematopoietic stem cells (HSCs) to the periphery occurs at a low frequency. It has been proposed that this phenomenon is part of a regenerative homeostatic mechanism that ensures the maintenance of hematopoiesis through the life of the individual. The administration of certain cytotoxic drugs or cytokines can enhance the mobilization of hematopoietic progenitors to the periphery. During the past 15 years, granulocyte‐colony stimulating factor (G‐CSF) has been used as (...) a standard cytokine for mobilization protocols in experimental models and in humans. Despite extensive efforts by multiple groups, a definitive mechanism explaining its role in mobilization has not been provided. In a recent paper, Katayama et al.,1 through a series of clever associations supported by well‐defined experimental systems, proposed that signals through the sympathetic nervous system modify the activity of the hematopoietic niche, acting as regulators of the mobilization of hematopoietic progenitors. This surprising finding adds a new level of complexity to the cellular milieu responsible for generation and maintenance of the hematopoietic niche. BioEssays 28: 687–691, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

¿En qué consiste la aplicación más justa de la ley, en aplicarla al pie de la letra en todos los casos o permitir al juez cierto margen para interpretarla? A lo largo de este texto presentaremos cómo no han sido pocos los partidarios de un “literalismo” a la hora de aplicar la ley, y para ello explicaremos lo sucedido durante la Revolución Francesa. Basados en la opinión de Rousseau, los ilustrados franceses creían que el legislador, en tanto que creador de (...) la ley, era el que mejor conocía el espíritu de la misma, luego la interpretación de la ley por parte del jurista era arbitraria. Dicho de otra manera: la labor del juez se entendía nada más como la inferencia de una conclusión a partir de ciertas premisas (la ley y el caso). Aristóteles, sin embargo, ya había previsto este problema. Entonces, el propósito de este escrito es (1) explicar qué ha llevado a querer aplicar la ley al pie de la letra, (2) cuáles son sus riesgos y (3) la solución que Aristóteles propone a este asunto, en donde hablaremos sobre la prudencia y el juez como «ley dotada de vida». (shrink)

This paper is an investigation into "abandonment of mental limit" in order to distinguish "being" and "thought". The philosophy of Leonardo Polo carries out that distinction with a study on "acts" and "habits" of knowledge. The difference between knowledge and being is exclusively the mental presence.

The only valid consideration of human being is what takes the person in his complexity. Human being is an open system in his relation with the medium. But, attending his racionality (deepest and most radical dimension), human being is free system. So, he is able to assert oneself ends according values.

Además del desafío propiamente jurídico que plantean la interamericanización del derecho y los proyectos que propugnan por un constitucionalismo transformador de las desigualdades sociales y políticas que aquejan a los países de la región, se plantean retos de naturaleza política. Sobresalen la inclusión social y la debida representación política. Dentro de los retos filosóficos se encuentra la depuración de conceptos que sofistiquen y precisen las categorías con las cuales describimos nuevos fenómenos en América Latina.

In this paper I show the importance of the methodical dimension in the philosophy of Leonardo Polo. This point is well illustrated in the recent book of Héctor Esquer Gallardo, El límite del pensamiento. La propuesta metódica de Leonardo Polo.

In this paper I show the importance of the methodical dimension in the philosophy of Leonardo Polo. This point is well illustrated in the recent book of Héctor Esquer Gallardo, El límite del pensamiento. La propuesta metódica de Leonardo Polo.

I am pleased to have been able to vindicate Plato from the oft-rehearsed charge of not having distinguished relations from qualities. Not only does Phaedo 102B7-C4 show quite clearly that he did make the proper distinction, but the theory of relations he adumbrated there is logically sound and ontologically viable. Furthermore, it is refreshing to think of relations not as Forms or universals, but as chains of ontologically tied universals.Naturally, now that we have a clear understanding of Plato's Phaedo theory (...) of relations and relational facts there is plenty of work to do. We must examine the other dialogues for alterations or even preservation of that theory. Moreover, there are those arguments of Aristotle that purport to reduce Plato's Theory of Forms to absurdity on account of relations. But of this I shall say more at some other time. (shrink)

Therapy for metaphysics -- Concepts, rules, and the spirit of recognition -- Meaning and meanings -- Reference and presence -- Truth and correspondence -- Emancipating theology.

The large number of sensors and actuators that make up the Internet of Things obliges these systems to use diverse technologies and protocols. This means that IoT networks are more heterogeneous than traditional networks. This gives rise to new challenges in cybersecurity to protect these systems and devices which are characterized by being connected continuously to the Internet. Intrusion detection systems are used to protect IoT systems from the various anomalies and attacks at the network level. Intrusion Detection Systems can (...) be improved through machine learning techniques. Our work focuses on creating classification models that can feed an IDS using a dataset containing frames under attacks of an IoT system that uses the MQTT protocol. We have addressed two types of method for classifying the attacks, ensemble methods and deep learning models, more specifically recurrent networks with very satisfactory results. (shrink)

RESUMEN El conocimiento utilizado para armar e implementar políticas socioeconómicas refiere por lo general a aseveraciones causales que pueden ser conceptuadas de diferentes maneras; sin embargo, estas suelen omitir un tema central: las consecuencias alternativas o los desvíos que emergen en caso de fracasar, lo que puede acarrear consecuencias negativas. Se argumenta que, para una buena implementación, es fundamental tener en cuenta dichas consecuencias alternativas, lo cual implica un cambio sustancial en el modo de tomar decisiones, donde la asimetría de (...) resultados es relevante. ABSTRACT The knowledge used to structure and implement socioeconomic policies generally refers to causal assertions that can be conceptualized differently; however, they tend to disregard the central issue of alternative consequences or deviations that arise in case of failure, which can cause negative effects. The paper argues that a successful implementation entails taking these alternative consequences into account. This implies a substantial change in the way decisions are made, in which the asymmetry of results becomes relevant. (shrink)

La filosofía estándar de la economía presupone que en el dominio de los fenómenos económicos subyacen regularidades estables, las cuales pueden explicarse mediante el funcionamiento de mecanismos o de máquinas socioeconómicas. Asimismo, se considera que una vez puestos en funcionamiento, su comportamiento no necesita de subsecuentes intervenciones. Esto implica asumir que los procesos socioeconómicos tienen una naturaleza semejante a los de las ciencias naturales. No obstante, dichas regularidades son por lo general examinadas a la luz de algún modelo económico, por (...) lo cual pierden muchas veces contacto con el mundo real. Este trabajo tiene como objetivo poner en el centro del análisis otro objeto de estudio: los procesos económicos basados en expectativas. Se trata de procesos en los cuales la acción humana funciona como nexo causal entre las variables económicas y en los que dicha acción es producto de una formación previa de expectativas, las cuales son sensibles a la información del contexto. Se mostrará que en esta clase de procesos la intervención sistemática sobre las condiciones de fondo y sobre las expectativas es fundamental si lo que se busca es alcanzar un objetivo deseado o lograr un proceso estable. Esta intervención requerirá no solo del conocimiento proporcionado por los modelos, sino también de un conocimiento extrateorético o interdisciplinario. Mainstream philosophy of economics assumes that steady regularities underlie the domain of economic phenomena which can be explained by the operation of mechanisms or socioeconomic machines. It is also considered that once operating those mechanisms don't need further interventions. This implies the assumption that the nature of socioeconomic processes is similar to the one of the natural sciences. Nevertheless, such regularities are usually examined in the light of some economic model, which often ends up losing contact with the real world. The present paper aims at putting in the center of the analysis another object of study: the economic processes based on expectations. In these processes the human action operates as a causal link between economic variables; such an action being the result of a previous building of expectations which are sensitive to the information of the context. It will be shown that the systematic intervention on the background conditions and expectations is fundamental in this kind of processes if what is sought is fulfilling a desired goal or managing a stable process. That intervention will not only require the knowledge provided by models but also an extra-theoretical or interdisciplinary knowledge. (shrink)

El conocimiento utilizado para armar e implementar políticas socioeconómicas refiere por lo general a aseveraciones causales que pueden ser conceptuadas de diferentes maneras; sin embargo, estas suelen omitir un tema central: las consecuencias alternativas o los desvíos que emergen en caso de fracasar, lo que puede acarrear consecuencias negativas. Se argumenta que, para una buena implementación, es fundamental tener en cuenta dichas consecuencias alternativas, lo cual implica un cambio sustancial en el modo de tomar decisiones, donde la asimetría de resultados (...) es relevante. (shrink)

The paper starts by distinguishing between two kinds of economic practice: theoretical economic practice (TEP) (model and theory building) and direct economic practice (DEP) (the practical operation upon real economies). Most of the epistemological and philosophical considerations have been directed to the first type of practice, one of whose main goals is the discovery of particular sorts of economic laws, mechanisms and other regularities which throw light on relevant economic patterns. We do not deny that in some restricted domains these (...) kinds of regularities may be found. Rather, we claim that the realm of economics is best understood as consisting of processes whose regular structure (if they have one at all) is not guaranteed beforehand but may be crucially influenced and successfully enforced by what we call DEP. We claim that (a) some economic processes are a particular type of social process that will be referred to as Expectations-Based Processes (EBP). Characteristically, an EBP shows a connection between the information that individuals receive from the relevant economic context, the expectations they form, and the actions they perform; (b) in those cases in which EBP exhibit a regular behaviour, they depend on agents' expectations and, crucially, we argue, on interventions upon them. Authorities as well as other economic actors may intervene to change agents' expectations (and therefore, their decisions), contributing to shape EBP and helping to produce the patterns that lead to some targeted economic phenomena. These features of EBP show that they are not shielded from external influences and they do not run autonomously once triggered. Therefore they cannot be conceived as mechanisms or as economic machines. Rather they are open-ended processes that require continuous prodding on the part of policy makers to keep them running in the intended way. (shrink)

Resumen: En el presente trabajo se argumenta que las diferencias entre los modelos económicos son básicamente diferencias en su parte seleccionada del mundo real que estos modelos intentan representar. Por lo tanto, lo que resulta importante es su rango de aplicabilidad a un sistema objetivo particular. A este respecto, se proporciona un enfoque basado en la similaridad de los modelos con un sistema objetivo y con los propósitos de los modeladores. También se argumenta que los modelos varían en valores de (...) similaridad. Estos valores ayudarán a los agentes a seleccionar el modelo que mejor cumpla la función de examinar algún fenómeno de interés.: In the present paper it is argued that differences among economic models are basically differences in their selected part of the real world these models try to account for. Therefore, what turns to be important is their range of applicability to a particular target system. In this respect, an approach based on the similarity of models to a target system and to the modelers’ purposes is provided. It is also argued that models vary in values of similarity. These values will help agents to select the model that best meets the role of examining some phenomenon of interest. (shrink)

In this paper subvarieties of pseudocomplemented distributive lattices are classified by their unification type. We determine the unification type of every particular unification problem in each subvariety of pseudocomplemented distributive lattices.

Bachelorarbeit aus dem Jahr 2009 im Fachbereich Philosophie - Theoretische (Erkenntnis, Wissenschaft, Logik, Sprache), Note: BA, Università degli Studi di Milano (Departement og Phliosophy), Veranstaltung: Phliosophy: Logic and Epistemology, Sprache: Italienisch.

Tomberlin's comparative claims about the superiority of the De Dicto-De Re Account over Guise Theory concerning referential opacity are abortively premature. Nevertheless, he may be right. Yet the order of the day is to develop the De Re-De Dicto Account to the hilt. Not until this is done can any useful dia-philosophical comparison of the two theories yield any fruit. My deep desire is, of course, for the sheer enjoyment of experiencing the world from the perspective of each of the (...) two views, indeed, from the perspective of other views — e.g., Frege's Sense/Referent Theory — that can be developed to the same data-encompassing stage as Guise Theory. (shrink)